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PLoS ONE 4:e8268 Pauls KAM et al (2021) Polyneuropathy monitoring in Parkinsons disease patients treated with levodopa/carbidopa intestinal gel

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Other concerns flagged included suspicions around the timeline between attaining ethical approval and actually commencing the study, the fact that the trial was not randomized considered by many to be the gold standard for clinical trials and the removal of four treated patients from the final dataset, three of whom were escalated to intensive care and one of whom died

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While results vary, many people report meaningful improvements in movement and reduced reliance on medication after treatment